Today, we will explore how CBD is emerging as an effective therapeutic alternative for all those who suffer from headaches. Its analgesic, anti-inflammatory and sedative properties, which act on both the physical and psychological levels, position CBD as a crucial tool not only to mitigate the symptoms linked to migraines, but also to attenuate their regularity and/or severity consistently and promote a notable improvement in quality of life.
CBD and Headaches
A comprehensive review conducted by Ethan Russo, which traces the history of the use of cannabis to relieve headaches, details how this plant has been used for centuries in the symptomatic therapy of migraines and headaches in various cultures, from Islamic, Indian, Chinese, to Greek and Roman. Specifically, between 1842 and 1942, it was a fundamental component of Western pharmacopoeias, being considered the remedy of choice for preeminent physicians to deal with migraine symptoms.
Today, recent advances in the Endocannabinoid System have allowed for a greater understanding of the mechanisms inherent in headaches and the role that phytocannabinoids could play in each particular case, especially CBD.
Due to the scientific findings made in recent years, a direct relationship has been evidenced between the mechanisms that can trigger headaches and migraines and the Endocannabinoid System (ECS) in particular:
- The activation of cannabinoid receptors (CB1 and CB2) and vanilloid receptors (TRPV) makes it possible to activate our body’s anti-inflammatory mechanisms and provides an analgesic effect.
- The ECS regulates the serotonergic (serotonin) and dopaminergic (dopamine) systems and interacts with the mechanisms of action of triptans and opioid pathways, playing a crucial role in the neuronal transmission of pain.
- Individuals suffering from chronic migraines show a noticeable decrease in the levels of Anandamide and 2-AG (the primordial endocannabinoids) and also a considerable increase in FAAH enzymes (those that degrade endocannabinoids)
These studies seem to support the hypothesis suggesting that disorders such as migraines could be rooted in ECS dysfunction, highlighting how a therapy focused on indirect stimulation of endocannabinoids (through inhibition of FAAHs) looks very promising, putting CBD in a position of relevance.
Effects of CBD on Headache
Although specific clinical trials on the use of CBD to treat migraines have not yet been conducted, much of the clinical evidence available in humans is based on individual or small group case studies, as well as anecdotal accounts and surveys.
However, thanks to current advances in research into the properties of CBD and the relationship between the Endocannabinoid System and the mechanisms of action of migraines and headaches, it has been found that Cannabidiol could offer even greater efficacy.
Effects of CBD on headaches/migraines
CBD is revealed as a tool of great value in the approach to headaches and their associated symptoms, thanks to its outstanding properties:
- Its anti-inflammatory and analgesic capacity is essential to relieve discomfort.
- On a physical level, it has relaxing properties, especially at the muscular level.
In the mental field, it acts as a relaxant, helping to improve mood. - In addition, its modulating action on the Endocannabinoid System allows an indirect increase in the levels of our own endocannabinoids.
However, it should be noted that headaches and migraines, although they share the main symptom of headache, are usually caused by different mechanisms. Therefore, the recommendations and routes of administration may vary according to each particular case.
How to Use CBD Oil for Headache
Dosage
It is crucial to keep in mind that CBD is a natural compound that interacts with other physiological systems, adapting to the body’s needs to restore its balance in a natural and sustainable way. This mainly implies that a larger amount does not guarantee a more intense or beneficial effect.
Therefore, there is an optimal dosage for each person, which can be discovered by starting with a minimum amount (about 10 mg of CBD divided into three daily doses) and gradually increasing (for example, adding about 10 mg of CBD every two to three days, depending on the response) until the desired effect is perceived. It is important to note that once the right dosage is found, it will remain relatively stable over time, as CBD does not generate tolerance, i.e. it is not required to increase the dose over time to obtain the same effects.
In any case, it is advisable to always consult with a specialist who provides follow-up, can advise on quality products (since the market is not regulated in Spain) and provides information on the legal framework corresponding to the country of residence.
Route of administration
In Spain it can only be done topically. We should gently massage the neck, forehead and temples area when necessary or preventively up to a maximum of 3-4 times a day. Its effect is limited to the area of application and can provide noticeable relief from symptoms, promoting muscle relaxation.
Is it safe to use?
According to studies conducted to date, CBD has been confirmed to have no toxic properties, even when administered for a long time or in high doses. If you want to learn more about the subject, we recommend you consult our article about the report issued by the WHO on the use of Cannabidiol. In this document you will find detailed information supported by scientific evidence about the non-toxic properties of CBD, which provides greater peace of mind and security to those considering its use.
Bibliography
- Baron, E. P. (2018). Medicinal properties of cannabinoids, terpenes, and flavonoids in cannabis, and benefits in migraine, headache, and pain: An update on current evidence and cannabis science. Headache: The Journal of Head and Face Pain, 58(7), 1139-1186.
- Russo, E. B. (2016). Clinical endocannabinoid deficiency reconsidered: Current research supports the theory in migraine, fibromyalgia, irritable bowel, and other treatment-resistant syndromes. Cannabis and Cannabinoid Research, 1(1), 154-165.
- Akerman, S., Holland, P. R., & Goadsby, P. J. (2013). Cannabinoid (CB1) receptor activation inhibits trigeminovascular neurons. Pain, 154(11), 2750-2758.
- Silberstein, S. D. (2020). The role of cannabinoids in headache disorders. Headache: The Journal of Head and Face Pain, 60(4), 885-890.
- Department of Health and Human Services. National Institutes of Health. National Center for Complementary and Integrative Health. (n.d.). Cannabis (Marijuana) and Cannabinoids: What You Need To Know.
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