Now that we know that cannabidiol could provide benefits, in today’s blog we are going to learn how CBD acts on the brain.
To understand the procedure that follows we must know the concept of what the endocannabinoid system is, if you do not remember it, we leave the link for you to refresh your memory.
Endocannabinoid System
The endocannabinoid system is responsible for homeostasis or balance between the different systems, it is involved in fertility, appetite regulation, pregnancy, pre- and postnatal development, the sensation of pain, mood, the pleasurable effects of voluntary exercise and memory formation.
The ECS plays an important role in the development of the human brain throughout a person’s life, and endocannabinoids such as anandamide and 2-arachidonoylglycerol (2-AG) play a huge role in brain development in both newborns and adolescent brain maturation.
When the endocannabinoid system is disrupted, health problems occur. since it can be altered by injuries or diseases, which can be part of an inflammatory event.
Probably, until you started to enter the world of CBD you had no idea that our body had an endocannabinoid system, which is enhanced by using CBD.
The relationship between CBD and the brain
Cannabidiol is a naturally occurring compound found in the cannabis sativa plant. CBD can be found in both hemp flower and cannabidiol oil formats.
CBD has positioned itself as a more than efficient product in the medical field since some researchers show that cannabidiol can treat neurological diseases since it protects neurons from degeneration, thus being able to slow down the development of visible symptoms in diseases such as Alzheimer’s. You can find more information in the literature studies. [
How CBD works on the brain
How does the brain function normally?
Neurons activate each other by means of neurotransmitters. Passing the information naturally to each other until a response is generated.
CBD in the human brain
Cannabis produces cannabinoids, substances that mimic others that are produced by the brain to regulate functions. These cannabinoids produced by the brain are called endocannabinoids that modify the functioning of neurons by connecting to structures called receptors.
We will imagine the receptors as a lock and the endocannabinoids are the keys that open these locks.
When they enter these locks, endocannabinoids reduce the degree of activation of neurons, which can generate a partial or generalized lack of control of the CNS (central nervous system). In other words, CBD acts as an inhibitor.
CBD uses the endocannabinoid system to reduce this neuronal activation, since when using cannabidiol it blocks its receptors and inhibits the regulation of these processes, reducing communication between cancer cells for example and could help according to various studies to relieve anxiety, insomnia, muscle pain, epilepsy episodes, etc…
Bibliography and Digital Sources
- Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis https://www.ncbi.nlm.nih.gov
- <span “>Zuardi AW. Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action. Rev. Bras. Psychiatr. 2008; 30(3):271-280.
- <span “>Reggio PH. The Cannabinoid Receptors. Greensboro: Springer Publishing; 2009. 402 p.
- <span “> Hernán Pérez de la Ossa, D., Lorente M., Gil-Alegre ME, Torres S, Garcia-Taboada E, Aberturas M.R. Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme. PLoS One 2013; 8(1):e54795. [ Links ]
- The anxiolytic effects of cannabidiol in chronically stressed mice are mediated by the endocannabinoid system: Role of neurogenesis and dendritic remodeling https://www.researchgate.net
- Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation – PubMedhttps://pubmed.ncbi.nlm.nih.gov
- Valdeolivas S, Satta V, Pertwee RG, Fernandez-Ruiz J, Sagredo O. Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington’s disease: role of CB1 and CB2 receptors. ACS Chem. Neurosci. 2012; 3 (5):400-406.
- <span “>Garcia C, Palomo-Garo C, Garcia-Arencibia M, Ramos J, Pertwee R, Fernandez-Ruiz J. Symptom-relieving and neuroprotective effects of the phytocannabinoid Delta(9)-THCV in animal models of Parkinson’s disease. Br. J. Pharmacol. 2011; 163(7):1495-1506.
- Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania – PubMedhttps://pubmed.ncbi.nlm.nih.gov
- Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expressionhttps://www.ncbi.nlm.nih.gov
- Normal average value of cerebral blood flow in younger adults is 50 ml/100 g/min – PubMed https://pubmed.ncbi.nlm.nih.gov
- SAGE Journals: Your gateway to world-class journal research https://journals.sagepub.com
- Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor – PubMed https://pubmed.ncbi.nlm.nih.gov
- Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series https://www.ncbi.nlm.nih.gov
- Frontiers | Anxiolytic Effects of Repeated Cannabidiol Treatment in Teenagers With Social Anxiety Disorders | Psychologyhttps://www.frontiersin.org
- Dopamine | Psychology Wiki | Fandom https://psychology.wikia.org
- Cannabidiol for the Treatment of Drug Use Disorders – ScienceDirect https://www.sciencedirect.com
- General Chemistry Online: The Bliss Molecule https://antoine.frostburg.edu
- Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophreniahttps://www.ncbi.nlm.nih.gov
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