Liposomal CBD represents a way of delivering CBD that leverages liposomal technology to improve the assimilation and availability of the compound in the body.
What is liposomal CBD?
Liposomal technology is based on the inclusion of CBD in tiny structures called liposomes, which are vesicles composed of a double lipid layer similar to cell membranes. These have the task of protecting CBD from enzymatic degradation and conducting it through the digestive system, in order to enhance its absorption.
By using liposomal CBD, an increase in the availability of the compound is anticipated compared to other forms of administration, such as conventional CBD oil . Availability refers to the amount and speed with which a compound is absorbed by the body and can be used effectively. With higher availability, it is feasible to achieve improved absorption and possibly to obtain faster and more effective results.
What are liposomes?
We can say that a liposome is basically a kind of vesicle used to encapsulate a drug. Typically, liposomes are made from substances known as phospholipids, which are the same molecules that make up our cell membranes. These molecules may play a key role in directing drug absorption or preventing drug degradation in the gastrointestinal tract.
The discovery of liposomes dates back to the 1960s, when they were developed with the purpose of improving the delivery of essential nutrients and drugs to the body. They have the particularity of being able to dissolve in both fats and water. In addition, the molecule contained inside the liposome is protected from degradation, which guarantees its safe arrival at its final destination.
What is the bioavailability of a substance?
When we talk about the bioavailability of an active component, we are referring to how quickly the plant-based compound is absorbed into the body. A high bioavailability indicates that the active substance enters the cells without difficulty and immediately unfolds its full range of effects. On the other hand, reduced bioavailability indicates a slower incorporation and release process, which could lead to the loss of valuable active ingredients due to a slow-running metabolism.
CBD liposomal oil boasts a high bioavailability, as it is not actually an oil. Its composition includes water, glycerin, terpenes, various cannabinoids and, in addition, the active component of curcumin.
What is CBD bioavailability?
The bioavailability of non-liposomal oral CBD products is low due to the lack of solubility of CBD in water. This results in limited absorption, around 9%. In contrast, inhaled CBD products have a higher bioavailability, approximately 31%.
It is important to know the bioavailability of the CBD products that are consumed in order to understand how much CBD the body can take advantage of. However, bioavailability does not necessarily refer to the amount that reaches the bloodstream, as it can theoretically exceed 100%. This means that the body may be available to carry more than 100% of the amount administered into the bloodstream.
What are the advantages of liposomal CBD over traditional CBD?
Liposomal CBD offers several advantages compared to traditional routes of CBD administration, such as oils or capsules. Here are some of the prominent benefits of liposomal CBD:
- Increased bioavailability: Liposomal CBD improves absorption in the intestine, allowing more CBD in the body.
- Fastest Action: Liposomal CBD offers faster action due to its better absorption and solubility in water.
- Increased stability: Liposomes provide stability to CBD, protecting it from environmental factors.
- Possible dose reduction: Liposomal CBD could reduce the dose needed for similar results.
- Greater comfort of use: Liposomal CBD is convenient as it is liquid and soluble in water, ideal for mixing with drinks or food.
Conclusions on Liposomal CBD
Finally, it is essential to highlight that research on the efficacy and specific benefits of liposomal CBD is still in development. Likewise, in Spain, the marketing of CBD products for domestic consumption is not authorized, as they can only be marketed as cosmetic products. Therefore, those consumers who ingest CBD products would be misusing them. The information provided in this text is aimed at countries where the consumption of CBD is allowed.
Bibliography and Digital Sources
- Akbarzadeh, A., Rezaei-Sadabady, R., Davaran, S., Joo, S. W., Zarghami, N., Hanifehpour, Y., … & Nejati-Koshki, K. (2013). Liposome: classification, preparation, and applications. Nanoscale research letters, 8(1), 1-9.
- Cherniakov, I., Izgelov, D., Domb, A. J., & Hoffman, A. (2017). The effect of Pro NanoLipospheres (PNL) formulation containing natural absorption enhancers on the oral bioavailability of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in a rat model. European Journal of Pharmaceutical Sciences, 109, 21-30.
- Millar, S. A., Stone, N. L., Yates, A. S., & O’sullivan, S. E. (2018). A systematic review on the pharmacokinetics of cannabidiol in humans. Frontiers in pharmacology, 9, 1365.
- Blair, E. Liposomal Cannabidiol Delivery: A Pilot Study.
- Blair, E. (2019). Next generation of liposomal delivery for cannabidiol from a hemp extract: a safety study. Amer J Endocan Med, 1(1), 20-22.
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